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"In 1953, James Watson and Francis Crick discovered the double helix structure of DNA. The discovery was a profound, Nobel-Prize-winning moment in the history of genetics, but it did not decipher the messages on the twisted ladderlike strands within our cells. No one knew what the human genome sequence actually was. No one had cracked the code of life. Now, at the beginning of a new millennium, that code has been cracked ... Here for the first time,...
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Completion of the Human Genome Project will make possible a staggering array of new medical technologies, including new diagnostic and screening tests for inherited disorders, gene therapies, and the ability to manipulate a person's inherited, non-disease traits. Most of the attention given to the social implications of these technologies has focused on their potential to harm the individual, for example, by denying employment or insurance. This book...
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"The Human Blueprint is an exciting and readable description of one of the greatest scientific enterprises of all time, the sequencing of the human genome. Robert Shapiro authoritatively tells us both what scientists are doing and some of the likely social implications of their work. His book will be of great interest to anyone who wishes to know about the shape of things to come," Gerald Feinberg, Columbia University, Professor of Physics.
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As the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way ... but the emerging picture is if anything far more exciting. Parrington gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating...
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"Welcome to the Genome takes you right into the thick of today's most cutting-edge science and its far-reaching implications. Authors Rob DeSalle and Michael Yudell have written a book which clearly explains the ongoing saga of our attempts to understand the mystery of biology's Rosetta Stone and use its code to better our lives." "This book employs an understandable style and full-color illustrations to provide insights into the complex science involved....
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The human genome, the complete set of genes housed in twenty-three pairs of chromosomes, is nothing less than an autobiography of our species. Spelled out in a billion three-letter words using the four-letter alphabet of DNA, the genome has been edited, abridged, altered and added to as it has been handed down, generation to generation, over more than three billion years. With the first draft of the human genome due to be published in 2000, we, this...
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The book examines how sophisticated tools of genetic analysis and manipulation are being developed in laboratories all over the world and considers the impact they will have on issues that scientists consider, including the causes of aging and death, the nature of the brain, and quality of life. Drawing from many research streams-such as advances in molecular and cell biology, imaging, and informatics-genetics is shown to encompass a view of nature...
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"The Human Genome: A User's Guide conveys both the essence and the excitement of modern human genetics. Incorporating all of researchers' latest discoveries, the authors ground their work in the discussion of a major function of the human gene: that of sex determination and development. This focus opens the discussion to the interactions between science and society. Hawley and Mori take care to examine the process of genetic analysis and to explore...
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"John Sulston was director of the Sanger Centre in Cambridge from 1993 to 2000. There he led the British arm of the international team selected to map the entire human DNA sequence, a feat that was pulled off in record time by an extraordinary collaboration of scientists. The ultimate success of the project, after innumerable setbacks and challenges from outside competitors, can be attributed in large part to John Sulston's own determination, passion...
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Table of contents Lecture 1.Natural history of the human genome Lecture 2.The mechanisms of mutation: how the human genome changes Lecture 3.Genetic diseases: the consequences of mutation Lecture 4.The human genome and medical practice Lecture 5.The mitochondrial genome and mitochondrial disorders Lecture 6.The genetic basis of cancer Lecture 7.The human genome and developmental biology.
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Description
In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes...
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"For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge...
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"Fifty years ago, James D. Watson, then just twenty-four, helped launch the greatest ongoing scientific quest of our time. Now, with unique authority and sweeping vision, he gives us the first full account of the genetic revolution - from Mendel's garden to the double helix to the sequencing of the human genome and beyond." "But genetics as we recognize it today - with its capacity, both thrilling and sobering, to manipulate the very essence of living...
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